CHO LAB RESEARCH

Receptor tyrosine kinases and monoclonal antibody drugs

RTKs are the cell surface receptors for growth factors and cytokines.
They have been key regulators of proliferation and development.
Overexpression or mutations in the receptors lead to activation of signal cascade resulting in
many types of cancers. Epidermal growth factor receptors (EGFRs) have been primary targets
in my LAB and anti-EGFR monoclonal antibody drugs are under structural studies to reveal
the mode of action (MOA) of the drugs.

Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

G protein-coupled receptors

GPCRs are 7-transmembrane domain receptors and comprise a large family of cell-surface
receptors that regulate many physiological functions, including visual sense, taste and smell,
regulation of the immune system and tumor growth and metastasis.
GPCRs are an important drug target and approximately 40% of all Food and Drug Administration (FDA)
approved drugs target. To develop new drugs targeting some GPCRs including chemokine receptors,
we are solving the 3D structure of receptors by x-ray crystallography and cryo_EM methods.