INSTITUTION AND LOCATION | DEGREE (if applicable) |
Completion Date MM/YYYY |
FIELD OF STUDY |
---|---|---|---|
Pohang Science and Technology Univ., Pohang | B.S. | 02/1996 | Life Science |
Pohang Science and Technology Univ., Pohang | Ph.D. | 02/2001 | Structural biology |
Johns Hopkins Medical School, Baltimore, MD | Postdoctoral | 06/2003 | Structural biology |
Hyun-Soo Cho
I have studied for the last 20 years how receptors on the membrane transduce extracellular signals across the membrane and the structures of enzymes including kinases, esterases, and glycosyltransferases. These receptors and enzymes are closely related to human diseases and most of them are promising therapeutic targets. I determined the crystal structures of EGFR family members, HER3, HER2 complexed with Herceptin antibody ( Science 2002, Nature 2003), and EGFR bound to a monoclonal antibody (GC1118) (Molecular Cancer Therapeutics 2016). Based on the structures, I illustrated the activation mechanism of the EGFR family and how the antibody works at the molecular level. My laboratory also studies other receptors such as 4-1BB bound to 4-1BB ligand (TNF receptor-TNF family) and Ftz-F1 bound to FTZ complex (nuclear receptor) (JBC 2010, JBC 2011). I determined the crystal structure of kinases such as MPK38, GSK3b, and DYRK3 with inhibitors (Acta D 2014, BBRC 2014, Oncotarget 2017). I also characterized the structure and mechanism of the pathogenic bacterial NleB/SseK glycosyltransferases (2018 Nat. Comm.).