CHO LAB RESEARCH TEAM

Lab Members

Professor

INSTITUTION AND LOCATION DEGREE
(if applicable)
Completion Date
MM/YYYY
FIELD OF STUDY
Pohang Science and Technology Univ., Pohang B.S. 02/1996 Life Science
Pohang Science and Technology Univ., Pohang Ph.D. 02/2001 Structural biology
Johns Hopkins Medical School, Baltimore, MD Postdoctoral 06/2003 Structural biology

Positions and Employment

  • 2001 - 2003 Post-doctoral Fellow, Johns Hopkins Medical School, MD, USA
  • 2003 - 2007 Assistant Professor, Yonsei University, Seoul, South Korea
  • 2007 - 2014 Assistant Professor, Yonsei University, Seoul, South Korea
  • 2014 - Present Professor, Yonsei University, Seoul, South Korea

Personal Statement.

Hyun-Soo Cho

I have studied for the last 20 years how receptors on the membrane transduce extracellular signals across the membrane and the structures of enzymes including kinases, esterases, and glycosyltransferases. These receptors and enzymes are closely related to human diseases and most of them are promising therapeutic targets. I determined the crystal structures of EGFR family members, HER3, HER2 complexed with Herceptin antibody ( Science 2002, Nature 2003), and EGFR bound to a monoclonal antibody (GC1118) (Molecular Cancer Therapeutics 2016). Based on the structures, I illustrated the activation mechanism of the EGFR family and how the antibody works at the molecular level. My laboratory also studies other receptors such as 4-1BB bound to 4-1BB ligand (TNF receptor-TNF family) and Ftz-F1 bound to FTZ complex (nuclear receptor) (JBC 2010, JBC 2011). I determined the crystal structure of kinases such as MPK38, GSK3b, and DYRK3 with inhibitors (Acta D 2014, BBRC 2014, Oncotarget 2017). I also characterized the structure and mechanism of the pathogenic bacterial NleB/SseK glycosyltransferases (2018 Nat. Comm.).

Research associate

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Graduate student

Alumni

연구교수

  • 전성훈 Jun Sung-Hoon 한국기초과학지원연구원 연구교수(책임연구원)
  • 이정 Lee Jung

박사 졸업

  • 차정석 Cha Jeong Seok 중앙대학교 post-doctor
  • 박준배 Park Junbae 서울대학교 post-doctor
  • 김국래 Kim Kuglae 연세대학교 약학대학 조교수
  • 조용순 Cho Yong-Soon 인제대학교 의과대학 조교수
  • 강영금 Kang YingJin ShanghaiTech University
  • 유지호 Yoo Ji-Ho 중앙대학교 약학대학 조교수
  • 김동욱 Kim Dong-Uk 삼성바이오로직스

석사

  • 원은영 Won Eun-Young
  • 정보람 Jeong Bo-Ram
  • 전종수 Jeon Jong-Soo CJ 제일제당
  • 조상길 Cho Sang-Gil 삼성바이오로직스
  • 김주연 Kim Juyeon 삼성바이오로직스
  • 벨린다 Ong Xiang Yu Belinda National University of Singapore 박사과정